CV

Prof. Peschel (*1950) conducts research in the field of haematology and tumor biology. By understanding the cell biological and molecular basics of tumor diseases, the basis for an individualized, targeted therapy for patients with leukaemia and cancer ist to be created. Acute and chronic leukaemias as well as tumor diseases of the lymphatic system (non-Hodgkin lymphomas) are the focus of fundamental and translational research. Prof. Peschel studied medicine at the University of Innsbruck, where he habilitated in 1989. From 1985-1987 he spent a research stay in the USA with William E.Paul, Laboratory of Immunology, at the National Institute of Health. 1990-1997 he worked as a senior physician (C3 professorship) at the University Hospital Mainz. In 1997 he was appointed to the newly founded Chair of Hematology and Internal Oncology at the Faculty of Medicine of the TUM.

 

Short biography

1968 – 1974	Studies in Medicine and doctorate, University Innsbruck
1975 – 1977	Assistent at the Pharmacological Institute, Innsbruck
1977 – 1979	Training as a rotating physician at the Regional Hospital Innsbruck
1979 – 1984	specialist medical training in  in internal medicine at the University Clinic for Internal Medicine, Innsbruck
1984 – 1985	Senior physician, University Clinic fo Internal Medicine, Innsbruck
1985 – 1987	Research stay with William E. Paul, Laboratorey of Immunology, National Institutes of Health, USA
1987 – 1990	Senior physician, Habilitation 1989, University Clinic for Internal Medicine, Innsbruck
1990 – 1997	Senior physician, III. medical clinic, Johannes Gutenberg-University, Mainz
1997 – 2017	Full professor of hematology, internal oncology and director of the III. Medical Clini of the Klinikum Rechts der Isar, Deputy Member of the Board of the Klinikum Rechts der Isar (1999-2004), Vice Dean (2003-2006), and Dean (20006-2007) of the department of medicine, TU Munich

 

Memberships and honors

Member in numerous professional societies

Member of the Central Commission for somatic gene therapy of the German Medical Association (1998-2006)

Member of the steering committee of the BMBF-funded excellence cluster "m4 Personalized Medicine" (2010-2015)

Member of the Senate and Grants Committee for Collaborative Research Centres of the Deutsche Forschungsgemeinschaft (german research council) (2010-2015)

Member of the expert committee for clinical cancer studies of the German Cancer Aid (2011-2020)

Co-Coordinator for TUM in the German Consortium for Translational Cancer Research in Munich 2011-2019)

Deputy Director of the Roman Herzog Cancer Center at the MRI (2009-2019)

External advisory board in various national and international collaborative reserach projects

 

Key publications

Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RA. Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med. 2017;214:165-181.

Wagner M, Oelsner M, Moore A, Götte F, Kuhn PH, Haferlach T, Fiegl M, Bogner C, Baxter EJ, Peschel C, Follows GA, Ringshausen I. Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia. Blood.2016;127:436-48.

Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U. GP130 activation induces myeloma and collaborates with MYC. J Clin Invest. 2014;124:5263-74.

Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M, Haferlach C, Kohlmann A, Schnittger S, Seifert M, Wanninger S, Zaborsky N, Oostendorp R, Ruland J, Leitges M, Kuhnt T, Schäfer Y, Lampl B, Peschel C, Egle A, Ringshausen I. Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell. 2013;23:77-92

Renstrom J, Istvanffy R, Gauthier K, Shimono A, Mages J, Jardon-Alvarez A, Kroger M, Schiemann M, Busch DH, Esposito I, Lang R, Peschel C, Oostendorp RA: "Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells". Cell Stem Cell. 2009; 5: 157-167.